Author

Lai N. Chan

Cleveland ClinicORCID 0000-0002-0371-2025Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Adriana Collins· 1 shared Benjamin KovaciciD· 1 shared Emma Stewart· 1 shared Grace M. Glasser· 1 shared Hua LouiD· 1 shared Mia Knupke· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

Adriana Collins

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

Cancer BiologyJournal of Biological ChemistryPeer-reviewedSep 9, 2026

Pathway incompatibility between NF-kB and RAS signaling constrains oncogenicity in B-cell leukemia

Emma Stewart, Adriana Collins, Benjamin Kovacic…·Lai N. Chan

The paper shows that NF-kB and RAS signaling pathways are incompatible in B-cell leukemia, with NF-kB suppressing RAS-driven oncogenesis through developmental signaling constraints.

DOI 10.1016/j.jbc.2026.113537

humanbulk RNA-seq

𝕏 PostBluesky