Author

Raphael Niklaus Sieber

Statens Serum InstitutORCID 0000-0002-0372-128XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:whole-genome sequencing· 2 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Organism:virus· 1

Frequent Co-Authors

Marc SteggeriD· 2 shared Morten Arendt RasmusseniD· 2 shared Amanda Gammelby QveseliD· 1 shared Anders FomsgaardiD· 1 shared Anders Gorm PederseniD· 1 shared Anders Krusager· 1 shared Anette Ella BoklundiD· 1 shared Anette G. BøtneriD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioinformatics

Marc SteggerORCID

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2 papers

Recent·Most cited

SARS-CoV-2 sequencing artifacts associated with targeted PCR enrichment and read mapping

Kirsten Ellegaard, Vithiagaran Gunalan, Raphael Niklaus Sieber, Sharmin Baig, Nicolai Balle Larsen, Marc Bennedbæk, Jonas Bybjerg‐Grauholm, Leandro Andrés Escobar-Herrera, Tobias Gress, Theis Hass Thorsen, Anders Krusager, Gitte Nygaard Aasbjerg, Nour Saad Al-Tamimi, Casper Westergaard, Christina Wiid Svarrer, , Marc Stegger

This study identifies sequencing artifacts in SARS-CoV-2 genome sequencing caused by PCR primers and reference genome choices, showing how they lead to ambiguous base calls and missed mutations.

PLoS ONE · Oct 16, 2025Peer-reviewedBioinformatics

Emergence and spread of SARS-CoV-2 variants from farmed mink to humans and back during the epidemic in Denmark, June-November 2020.

Thomas Bruun Rasmussen, Amanda Gammelby Qvesel, Anders Gorm Pedersen, Ann Sofie Olesen, Jannik Fonager, Morten Rasmussen, Raphael Niklaus Sieber, Marc Stegger, Francisco Fernando Calvo-Artavia, Marlies Jilles Francine Goedknegt, Esben Rahbek Thuesen, Louise Lohse, Sten Mortensen, Anders Fomsgaard, Anette Ella Boklund, , Graham J. Belsham

This study tracks the emergence and spread of SARS-CoV-2 variants between mink and humans in Denmark, identifying multiple transmission routes and estimating cross-species transmission events.

PLoS Pathogens · Jul 1, 2024Peer-reviewedMicrobiology