Author

Nicolai Balle Larsen

Statens Serum InstitutORCID 0000-0001-5105-7056Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:variant calling· 1 Organism:virus· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Alan O. GaoiD· 1 shared Anders Krusager· 1 shared Casper WestergaardiD· 1 shared Christina Wiid SvarreriD· 1 shared Gitte Nygaard AasbjergiD· 1 shared Irene GallinaiD· 1 shared Johannes C. WalteriD· 1 shared Jonas Bybjerg‐GrauholmiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Alan O. GaoORCID

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2 papers

Recent·Most cited

BioinformaticsPLoS ONEPeer-reviewedOct 16, 2025

SARS-CoV-2 sequencing artifacts associated with targeted PCR enrichment and read mapping

Kirsten Ellegaard, Vithiagaran Gunalan, Raphael Niklaus Sieber…·Marc Stegger

This study identifies sequencing artifacts in SARS-CoV-2 genome sequencing caused by PCR primers and reference genome choices, showing how they lead to ambiguous base calls and missed mutations.

1 citation

viruswhole-genome sequencing

𝕏 PostBluesky

Molecular BiologybioRxivPreprintAug 1, 2018

Mechanism of replication-coupled DNA-protein crosslink proteolysis by SPRTN and the proteasome

Alan O. Gao, Nicolai Balle Larsen, Justin L. Sparks…·Julien P. Duxin

This study shows that both SPRTN and the proteasome degrade DNA-protein crosslinks during DNA replication, using distinct mechanisms involving ubiquitylation and polymerase extension.

2 citations

experimental assay

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