Author

Kiran Sankar Chatterjee

Scripps Research InstituteORCID 0000-0002-0392-6779Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1

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H. Jane DysoniD· 1 shared Maria A. Martinez‐YamoutiD· 1 shared Peter E. WrightiD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperBiophysics

H. Jane DysonORCID

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1 paper

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BiophysicsJournal of Molecular BiologyPeer-reviewedSep 26, 2025

Linker Length and Composition within Disordered Binding Motifs modulates the Avidity and Reversibility of a Multivalent Protein Interaction Switch

Kiran Sankar Chatterjee, Maria A. Martinez‐Yamout, H. Jane Dyson, Peter E. Wright

The paper investigates how linker length and composition in HIF-1 affect its binding affinity and competition with CITED2 for TAZ1, revealing the role of flexibility and electrostatic interactions in modulating the hypoxic switch.

2 citations

humanprotein structure

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