Author

Brian L. Frey

University of Wisconsin–MadisonORCID 0000-0002-0397-7269Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Assay:metagenomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Lloyd M. SmithiD· 3 shared Michael R. ShortreediD· 2 shared Anthony J. CesnikiD· 1 shared Burke NiegoiD· 1 shared Dhruv BhattaramiD· 1 shared Khairina Ibrahim· 1 shared Lei LüiD· 1 shared Mark Scalf· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBioengineering

Lloyd M. SmithORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Chemoselective Characterization of New Extracellular Matrix Deposition in Bioengineered Tumor Tissues

Zihan Ling, Burke Niego, Qingyang Li, Dhruv Bhattaram, Vanessa Serna Villa, Michael Y. Hu, Zhuowei Gong, Lloyd M. Smith, Brian L. Frey, Xi Ren

This study develops a chemoselective method to profile newly synthesized extracellular matrix proteins in bioengineered tumor tissues, revealing distinct ECM synthesis patterns in response to different extracellular environments.

Advanced Materials · Sep 6, 2025Peer-reviewedBioengineering

Discovery of dehydroamino acids and their crosslinks in Tau and other aggregating proteins of Alzheimers disease

Samuel W. Markovich, Brian L. Frey, Mark Scalf, Michael R. Shortreed, Lloyd M. Smith

This study identifies dehydroamino acids and their crosslinks in Alzheimer's disease brain proteome, showing increased prevalence in AD compared to controls.

Brain Communications · Dec 24, 2024Peer-reviewedBiochemistry

Spritz: A Proteogenomic Database Engine

Anthony J. Cesnik, Rachel Miller, Khairina Ibrahim, Lei Lü, Robert J. Millikin, Michael R. Shortreed, Brian L. Frey, Lloyd M. Smith

Spritz generates sample-specific proteogenomic databases annotated with sequence variations and PTMs from RNA-seq data, enabling improved identification of proteoforms in mass spectrometry analyses.

Journal of Proteome Research · Sep 23, 2020Peer-reviewedBioinformatics