Xi Ren

This paper develops an interstitium-mimicking alveolar membrane for lung-on-chip systems that enables physiologic aerosol transport and reveals distinct acute-chronic lung injury responses.

This paper introduces dECM-AoAO organoids that better recapitulate native airway epithelial composition and function compared to ECM-free models.

This study develops a chemoselective method to profile newly synthesized extracellular matrix proteins in bioengineered tumor tissues, revealing distinct ECM synthesis patterns in response to different extracellular environments.

The paper introduces AggreBots, a platform for creating designer motility patterns in multicellular tissues by spatially controlling the aggregation of epithelial spheroids, achieving greater motility than traditional CiliaBots.

This paper develops a method to simultaneously differentiate cardiac and lung epithelial lineages from human pluripotent stem cells to study cardio-pulmonary interactions during embryogenesis.