Author

Mark Scalf

University of Wisconsin–Madison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 3 Biochemistry· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Lloyd M. SmithiD· 6 shared Randal S. TibbettsiD· 4 shared Sang Hwa KimiD· 4 shared Weiyan JiaiD· 3 shared Claire E. Boos· 2 shared Adam S. Mastrocola· 1 shared Adenine Si-Hui KooiD· 1 shared Aditya BajajiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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6 shared papersMolecular Biology

Lloyd M. SmithORCID

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6 papers

Recent·Most cited

DNA-damage dependent isoform switching modulates RIF1 DNA repair complex assembly and phase separation

Adenine Si-Hui Koo, Weiyan Jia, Sang Hwa Kim, Mark Scalf, Claire E. Boos, Yuhong Chen, Demin Wang, Andrew F. Voter, Aditya Bajaj, Lloyd M. Smith, James L. Keck, Christopher J. Bakkenist, Lin E. Guo, Randal S. Tibbetts

This study shows DNA damage induces alternative splicing of RIF1, generating isoforms that affect DNA repair complex assembly and phase separation.

Journal of Biological Chemistry · Oct 25, 2025Peer-reviewedMolecular Biology

Interactome screening implicates BAG6 as a suppressor of UBQLN2 misfolding in ALS-dementia

Sang Hwa Kim, Claire E. Boos, Mark Scalf, Akasha K Wilkemeyer, Lloyd M. Smith, Randal S. Tibbetts

The paper identifies BAG6 as a suppressor of UBQLN2 misfolding in ALS-dementia by analyzing interactome changes in mutant UBQLN2 proteins.

bioRxiv · Oct 15, 2025 · PreprintMolecular Biology

Discovery of dehydroamino acids and their crosslinks in Tau and other aggregating proteins of Alzheimers disease

Samuel W. Markovich, Brian L. Frey, Mark Scalf, Michael R. Shortreed, Lloyd M. Smith

This study identifies dehydroamino acids and their crosslinks in Alzheimer's disease brain proteome, showing increased prevalence in AD compared to controls.

Brain Communications · Dec 24, 2024Peer-reviewedBiochemistry

Defining distinct RNA-protein interactomes of SARS-CoV-2 genomic and subgenomic RNAs

Isabella T. Whitworth, Rachel A. Knoener, Maritza Puray‐Chavez, Peter Halfmann, Sofia Romero, M’bark Baddouh, Mark Scalf, Yoshihiro Kawaoka, Sebla B. Kutluay, Lloyd M. Smith, Nathan M. Sherer

The paper identifies RNA-protein interactomes of SARS-CoV-2 genomic and subgenomic RNAs, revealing new host factors involved in viral replication and antiviral defense.

Journal of Proteome Research · Dec 3, 2023Peer-reviewedMolecular Biology

Axon guidance pathways modulate neurotoxicity of ALS-associated UBQLN2

Sang Hwa Kim, Kye D Nichols, Eric Nathaniel Anderson, Yining Liu, Nandini Ramesh, Weiyan Jia, Connor J Kuerbis, Mark Scalf, Lloyd M. Smith, Udai Bhan Pandey, Randal S. Tibbetts

This study identifies axon guidance pathways as modulators of UBQLN2 toxicity in ALS/FTD, showing reduced neurodegeneration with UNC5B and DCC suppression in multiple models.

eLife · Apr 11, 2023Peer-reviewedNeuroscience

Fused in sarcoma regulates DNA replication timing and progression

Weiyan Jia, Sang Hwa Kim, Mark Scalf, Peter Tonzi, Robert J. Millikin, William M. Guns, Lu Liu, Adam S. Mastrocola, Lloyd M. Smith, Tony T. Huang, Randal S. Tibbetts

This study identifies FUS's role in DNA replication timing and progression, showing its importance in genome stability and its potential contribution to disease.

Journal of Biological Chemistry · Aug 8, 2021Peer-reviewedGenomics