Epigenetic Reprogramming Alters Intestinal Stem Cell Fate in Pouchitis
Chaoting Zhou, Shan Liu, Jing Yu Carolina Cen Feng, Katherine S. Ventre, Tianyi Li, Jordan E. Axelrad, Kyung Ku Jang, Ken Cadwell
This study shows that inflammation in pouchitis alters intestinal stem cell fate through epigenetic changes, which can be reversed by JAK/STAT therapies.
bioRxiv · Mar 19, 2025 · PreprintCell Biology