Author

Shan Liu

University of PennsylvaniaORCID 0000-0002-2192-0119Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Chaoting ZhouiD· 2 shared Ken CadwelliD· 2 shared Marco RuellaiD· 2 shared Adam BaggiD· 1 shared Adam Barsouk· 1 shared Alain H. RookiD· 1 shared Alberto CarturaniD· 1 shared Andrew Evan Lee· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersImmunology

Chaoting ZhouORCID

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3 papers

Recent·Most cited

A defined multi-kingdom microbial consortium naturalizes the immune system of laboratory mice

Yi Yang, Shan Liu, Chaoting Zhou, Nile Bayard, Siddharth R. Krishnamurthy, Elias Roth Gerrick, Michael R. Howitt, Sebastian Shaw, Boris Striepen, Marco Ruella, Ken Cadwell

The paper identifies a multi-kingdom microbial consortium that normalizes immune responses in laboratory mice, altering cancer outcomes and CAR T cell therapy responses.

bioRxiv · Oct 16, 2026 · PreprintImmunology

Harnessing the CD2 axis to broaden and enhance the efficacy of CAR T cell therapies

Alberto Carturan, Mathew G. Angelos, Puneeth Guruprasad, Ruchi P. Patel, Raymone Pajarillo, Andrew Evan Lee, Yunlin Zhang, Wei Xie, Jesse L. Rodriguez, Jaryse Harris, Pooja Devi, Olabisi I. Afolayan-Oloye, Jason Xu, Jonathan H. Sussman, Omar Elghawy, , Marco Ruella

This paper develops anti-CD2 CAR T-cells that overcome fratricide and improve efficacy by incorporating a PD-1:CD2 switch receptor to restore CD2 signaling.

Blood · Jan 5, 2026Peer-reviewedCancer Biology

Epigenetic Reprogramming Alters Intestinal Stem Cell Fate in Pouchitis

Chaoting Zhou, Shan Liu, Jing Yu Carolina Cen Feng, Katherine S. Ventre, Tianyi Li, Jordan E. Axelrad, Kyung Ku Jang, Ken Cadwell

This study shows that inflammation in pouchitis alters intestinal stem cell fate through epigenetic changes, which can be reversed by JAK/STAT therapies.

bioRxiv · Mar 19, 2025 · PreprintCell Biology