Jordan E. Axelrad

The paper identifies MAIT cell enrichment in Lynch syndrome carriers without CRC, linked to immune surveillance and reduced cancer risk.

The paper shows that IFN-β and IFN-λ, along with TNF, promote epithelial cell death in mice and human organoids, especially in those with ATG16L1 mutations, linking it to intestinal disease.

This study shows that inflammation in pouchitis alters intestinal stem cell fate through epigenetic changes, which can be reversed by JAK/STAT therapies.

This study uses patient-derived intestinal organoids to predict individual clinical responsiveness to tofacitinib in ulcerative colitis by assessing drug sensitivity and MATE1 expression.

The paper characterizes antigen-specific CD8+ T cells post-SARS-CoV-2 vaccination and infection using multimodal sequencing, identifying unique biomarkers and clinical predictors.