Ken Cadwell

The paper identifies a multi-kingdom microbial consortium that normalizes immune responses in laboratory mice, altering cancer outcomes and CAR T cell therapy responses.

The paper creates a single-cell and spatial transcriptomics atlas of the ileum during diverse infections, revealing novel cell states and immune responses.

The paper profiles mouse CD4+ T cells across >700 samples to identify 20 molecular states, revealing diverse effector functions and unexpected similarities between Tfh and chronically stimulated states.

The paper tests a new peer-review model that separates scientific quality from impact, showing reviewers can effectively evaluate both dimensions and participants support its adoption.

immgenT creates a comprehensive T-cell molecular atlas across mouse organs and disease states, identifying 8 lineages and 107 clusters using deep generative models and integrating external datasets.

The paper identifies MAIT cell enrichment in Lynch syndrome carriers without CRC, linked to immune surveillance and reduced cancer risk.

This study shows that misoprostol reduces C. difficile infection severity by decreasing neutrophil infiltration and G-CSF levels, highlighting innate immune modulation as a therapeutic strategy.

The paper shows that IFN-β and IFN-λ, along with TNF, promote epithelial cell death in mice and human organoids, especially in those with ATG16L1 mutations, linking it to intestinal disease.

The paper shows that suppressing both COX-1 and COX-2 does not cause intestinal injury in mice unless combined with specific NSAIDs, and that gut microbiome changes amplify NSAID-induced enteropathy.

The paper identifies TCR-V gene usage patterns in T cells sorted by anti-TCR mAbs using single-cell RNAseq and finds enriched ERV1-family LTR expression in specific TRBV regions.

The paper examines T cell changes in mammary glands during pregnancy and lactation, finding an expansion of T effector cells and similarities to intestinal T cells.

The paper shows that stress from environmental change can clear a persistent enteric virus by inducing immune responses and reducing viral persistence.

This study shows that inflammation in pouchitis alters intestinal stem cell fate through epigenetic changes, which can be reversed by JAK/STAT therapies.

This study shows female mice clear MRSA from the gut faster than males, relying on gut microbiota and Th17 cells, while ovariectomy reduces this resistance.

This study shows that gut microbiota depletion allows MRSA to adapt through genetic changes that enhance colonization fitness but reduce antimicrobial resistance and virulence.

This study uses patient-derived intestinal organoids to predict individual clinical responsiveness to tofacitinib in ulcerative colitis by assessing drug sensitivity and MATE1 expression.

The paper shows that heterozygosity for the ATG16L1 T300A allele protects against Salmonella infection, while homozygosity increases susceptibility.