Megan S. Lim

This study uses spatial transcriptomics and single-cell analysis to reveal how MDS bone marrow microenvironments are altered, showing TGFβ dysregulation in malignant cells and immune escape mechanisms.

This study identifies unique transcriptional features of Hodgkin lymphoma HRS cells, including immune evasion mechanisms and an unfolded protein response, distinguishing them from other B-cell lymphomas.

The paper shows that mTORC1 signaling hypersensitivity to leucine drives an onco-circuit in T cell malignancy, and a low leucine diet is therapeutic without impairing T cell immunity.