Mikhail Roshal

Ecological determinants of disease and immunity in myelodysplastic syndromes

This study uses spatial transcriptomics and single-cell analysis to reveal how MDS bone marrow microenvironments are altered, showing TGFβ dysregulation in malignant cells and immune escape mechanisms.

Transcriptome sequencing of Hodgkin lymphoma Hodgkin and Reed-Sternberg cells reveals escape from NK cell recognition and an unfolded protein response

This study identifies unique transcriptional features of Hodgkin lymphoma HRS cells, including immune evasion mechanisms and an unfolded protein response, distinguishing them from other B-cell lymphomas.

Enhanced clinical assessment of hematologic malignancies through routine paired tumor:normal sequencing

This study presents a paired tumor:normal sequencing dataset for hematologic malignancies, showing improved identification of somatic variants and their clinical relevance.