Isabella Y. Kong

A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease

This study identifies dysregulated epithelial cell death signaling in inflammatory bowel disease, showing it persists during remission despite therapy.

The HUSH Complex Dictates EBV-transformed B cell Sensitivity to NK Cell Surveillance Through Repression of NKG2A Ligand γ-Proto-cadherin

The paper identifies the HUSH complex as a regulator of EBV-transformed B cell sensitivity to NK cell surveillance by repressing the NKG2A ligand γ-protocadherin.

Transcriptome sequencing of Hodgkin lymphoma Hodgkin and Reed-Sternberg cells reveals escape from NK cell recognition and an unfolded protein response

This study identifies unique transcriptional features of Hodgkin lymphoma HRS cells, including immune evasion mechanisms and an unfolded protein response, distinguishing them from other B-cell lymphomas.

C3aR1 on β cells enhances β cell function and survival

This study shows that C3aR1 on β cells improves β cell function and survival, especially in obesity and T2D, by enhancing insulin secretion and reducing cell death.

A PP2A-Integrator complex fine-tunes transcription by opposing CDK9

The paper identifies a PP2A-Integrator complex that opposes CDK9 activity to regulate transcription and shows its therapeutic synergy in leukemia.