Author

Alan Gilbert Christoffels

South African Medical Research CouncilORCID 0000-0002-0420-2916Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:bacteria (other)· 1 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Melanie GrobbelaariD· 2 shared Collins Kipngetich TanuiiD· 1 shared Harris OnyweraiD· 1 shared Hocine BendouiD· 1 shared Mohd ShahbaaziD· 1 shared Mosoka Papa FallahiD· 1 shared Nebiyu DerejeiD· 1 shared Peter Van HeusdeniD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBioinformatics

Melanie GrobbelaarORCID

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintAug 27, 2025

Artificial Intelligence for Genomics and Bioinformatics: Is Africa Lagging Behind?

Sofonias Kifle Tessema, Collins Kipngetich Tanui, Harris Onywera…·Yenew Kebede

The paper surveys AI usage in African genomics research and finds low familiarity with AI applications among researchers.

DOI 10.1101/2025.08.27.668885

statistical modelbenchmarking

𝕏 PostBluesky

BioinformaticsbioRxivPreprintJun 14, 2022

Condition-Specific Mapping of Operons (COSMO) using dynamic and static genome data

Tracey Calvert-Joshua, Hocine Bendou, Peter Van Heusden…·Alan Gilbert Christoffels

COSMO predicts operons in Mycobacterium tuberculosis using RNA-seq data, outperforming existing predictors in accuracy and condition-specific operon detection.

DOI 10.1101/2022.06.14.496048

bacteria (other)bulk RNA-seq

𝕏 PostBluesky

BioinformaticsbioRxivPreprintJul 30, 2020

Repurposing Novobiocin for activity against latency associated Mycobacterium tuberculosis drug target nicotinate-nucleotide adenylyltransferase (Rv2421c)

Ruben E.A. Cloete, Mohd Shahbaaz, Melanie Grobbelaar…·Alan Gilbert Christoffels

The paper identifies Novobiocin as a potential repurposed drug against Mycobacterium tuberculosis by targeting Rv2421c, through computational screening and in vitro validation.

DOI 10.1101/2020.07.30.228726

statistical modeldrug response / drug discovery

𝕏 PostBluesky