Author

Melanie Grobbelaar

South African Medical Research CouncilORCID 0000-0001-8138-5376Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Organism:bacteria (other)· 1 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alan Gilbert ChristoffelsiD· 2 shared Hocine BendouiD· 1 shared Mohd ShahbaaziD· 1 shared Peter Van HeusdeniD· 1 shared Robin M. WarreniD· 1 shared Ruben E.A. CloeteiD· 1 shared Samantha Leigh SampsoniD· 1 shared Tracey Calvert-JoshuaiD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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2 shared papersBioinformatics

Alan Gilbert ChristoffelsORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintJun 14, 2022

Condition-Specific Mapping of Operons (COSMO) using dynamic and static genome data

Tracey Calvert-Joshua, Hocine Bendou, Peter Van Heusden…·Alan Gilbert Christoffels

COSMO predicts operons in Mycobacterium tuberculosis using RNA-seq data, outperforming existing predictors in accuracy and condition-specific operon detection.

DOI 10.1101/2022.06.14.496048

bacteria (other)bulk RNA-seq

𝕏 PostBluesky

BioinformaticsbioRxivPreprintJul 30, 2020

Repurposing Novobiocin for activity against latency associated Mycobacterium tuberculosis drug target nicotinate-nucleotide adenylyltransferase (Rv2421c)

Ruben E.A. Cloete, Mohd Shahbaaz, Melanie Grobbelaar…·Alan Gilbert Christoffels

The paper identifies Novobiocin as a potential repurposed drug against Mycobacterium tuberculosis by targeting Rv2421c, through computational screening and in vitro validation.

DOI 10.1101/2020.07.30.228726

statistical modeldrug response / drug discovery

𝕏 PostBluesky