Author

Ruben E.A. Cloete

South African Medical Research CouncilORCID 0000-0003-1966-0212Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 3

Signature Assays, Organisms & Methods

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Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:simulation· 1

Frequent Co-Authors

Adetayo Emmanuel ObasaiD· 1 shared Alan Gilbert ChristoffelsiD· 1 shared Burtram Clinton FieldingiD· 1 shared Dewald SchoemaniD· 1 shared Graeme Brendon JacobsiD· 1 shared Melanie GrobbelaariD· 1 shared Mohd ShahbaaziD· 1 shared Rumbidzai Chitongo· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperBioinformatics

Adetayo Emmanuel ObasaORCID

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3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintMar 8, 2021

Comparative studies of the seven human coronavirus envelope proteins using topology prediction and molecular modelling to understand their pathogenicity

Dewald Schoeman, Ruben E.A. Cloete, Burtram Clinton Fielding

The paper predicts the topologies and models 3D structures of all seven human coronavirus E proteins to understand differences in pathogenicity between virulent and less virulent strains.

3 citations

humanprotein structure

𝕏 PostBluesky

BioinformaticsbioRxivPreprintJul 30, 2020

Repurposing Novobiocin for activity against latency associated Mycobacterium tuberculosis drug target nicotinate-nucleotide adenylyltransferase (Rv2421c)

Ruben E.A. Cloete, Mohd Shahbaaz, Melanie Grobbelaar…·Alan Gilbert Christoffels

The paper identifies Novobiocin as a potential repurposed drug against Mycobacterium tuberculosis by targeting Rv2421c, through computational screening and in vitro validation.

DOI 10.1101/2020.07.30.228726

statistical modeldrug response / drug discovery

𝕏 PostBluesky

BioinformaticsPLoS ONEPeer-reviewedMay 7, 2020

Molecular dynamic simulations to investigate the structural impact of known drug resistance mutations on HIV-1C Integrase-Dolutegravir binding

Rumbidzai Chitongo, Adetayo Emmanuel Obasa, Sello Given Mikasi…·Ruben E.A. Cloete

This study uses molecular dynamics simulations to analyze how known drug resistance mutations affect the structure and binding of HIV-1C Integrase with Dolutegravir.

29 citations

protein structuresimulation

𝕏 PostBluesky