Philippe M. Soriano

This study identifies diverse Fgfr1 signaling pathways and endocytic trafficking mechanisms that regulate early mesoderm development, revealing both canonical and non-canonical roles beyond traditional signaling cascades.

The paper shows that GRB2 binding to the C-terminal of FGFR2, independent of FRS2, is not essential for embryonic development or adult homeostasis.

This study shows that FGF signaling regulates salivary gland branching by modulating cell adhesion, with non-canonical mechanisms involved.

This study investigates the role of SRF cofactors in neural crest development, showing that MRTF-mediated SRF activity is critical for cardiac neural crest function while TCF-mediated activity is essential for cranial neural crest.

This study investigates FGF signaling beyond canonical pathways by analyzing Fgfr1 and Fgfr2 mutations in mice, revealing novel kinase-dependent cell adhesion properties independent of traditional signaling cascades.