James F. Clark

A prime-editing recorder in one mouse embryo yields a dated, zygote-rooted lineage tree of 1.28M cells at E13.5, enabling clonal dominance, sibling-fate and cell-type coupling analyses.

This study identifies diverse Fgfr1 signaling pathways and endocytic trafficking mechanisms that regulate early mesoderm development, revealing both canonical and non-canonical roles beyond traditional signaling cascades.

The paper shows that GRB2 binding to the C-terminal of FGFR2, independent of FRS2, is not essential for embryonic development or adult homeostasis.

The paper identifies cuticle collagen genes as downstream effectors of the DBL-1/BMP pathway in regulating body size in C. elegans and shows direct regulation through Smad binding elements.