Author

J. Richard Brewer

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Esen SefikiD· 3 shared Richard Anthony FlavelliD· 3 shared Ailin Han· 2 shared Amin H. NassariD· 2 shared Holly N. BlackburniD· 2 shared Tianli XiaoiD· 2 shared Walter K. MoweliD· 2 shared Aimee Wu· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersImmunology

Esen SefikORCID

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Author profile →

4 papers

Recent·Most cited

Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency

Tianli Xiao, J. Richard Brewer, Maximillian J. Carlino, Ailin Han, Yamato J. Takabe, Chia‐Yi Lee, Fengrui Zhang, Mi Chen, Holly N. Blackburn, Amin H. Nassar, Qiankun Wang, Kristen Brennand, Liang Shan, Esen Sefik, Diane S. Krause, Richard Anthony Flavell

This study uses reverse genetics in humanized mice to show that DPP9 deficiency causes CARD8-mediated pyroptosis in human hematopoietic stem and progenitor cells, leading to pancytopenia.

Journal of Clinical Investigation · Sep 14, 2026Peer-reviewedImmunology

DPP9-mediated inflammasome repression protects against checkpoint inhibitor lung toxicity

J. Richard Brewer, Ailin Han, Amin H. Nassar, Elias Bou Farhat, Holly N. Blackburn, Tianli Xiao, Haris Mirza, Walter K. Mowel, Esen Sefik, Saskia Hartner, Michael Chiorazzi, Takeshi Ito, Min Hee Oh, Matthew Z. Madden, Athreya S Rangavajhula, , Richard Anthony Flavell

The paper identifies DPP9 as a genetic susceptibility gene for checkpoint inhibitor pneumonitis and shows IL-18 blockade could be a therapeutic strategy.

bioRxiv · Jul 3, 2026 · PreprintImmunology

IL-4 Licenses B Cell Activation Through Cholesterol Synthesis

Holly R. Steach, Autumn Gabrielle York, Jonathan R. Mattingly, Mathias H. Skadow, Shuting Chen, Jun Zhao, Kevin J. Williams, Quan Zhou, Weu-Yuan Hsieh, J. Richard Brewer, Rihao Qu, Justin A. Shyer, Christian Harman, Esen Sefik, Walter K. Mowel, , Richard Anthony Flavell

This study shows IL-4 promotes B cell activation by upregulating cholesterol synthesis, which is essential for ER expansion, cell cycle progression, and proliferation during influenza infection.

bioRxiv · May 13, 2024 · PreprintImmunology

FGF signaling in development beyond canonical pathways

Ayan T. Ray, Pierre Mazot, J. Richard Brewer, Catarina Catela, Colin J. Dinsmore, Philippe M. Soriano

This study investigates FGF signaling beyond canonical pathways by analyzing Fgfr1 and Fgfr2 mutations in mice, revealing novel kinase-dependent cell adhesion properties independent of traditional signaling cascades.

Genes & Development · Dec 1, 2020Peer-reviewedDevelopmental Biology