Author

Alexander I.H. Siddiqui

University of OxfordORCID 0000-0002-0433-5081Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

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Charlotte DeaneiD· 1 shared Maria MusgaardiD· 1 shared Oliver M. CrookiD· 1 shared R. SkyneriD· 1 shared Srinath KrishnamurthyiD· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperBiophysics

Charlotte DeaneORCID

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1 paper

Recent·Most cited

BiophysicsbioRxivPreprintMar 4, 2026

A framework for testing structural hypotheses of protein dynamics against experimental HDX-MS data

Alexander I.H. Siddiqui, R. Skyner, Maria Musgaard…·Oliver M. Crook

The paper introduces ValDX, a framework to validate and quantify uncertainty in HDX-MS data integration with protein structural ensembles, showing it outperforms conventional metrics in distinguishing correct from incorrect models.

DOI 10.64898/2026.03.02.709114

proteomicsstatistical model

𝕏 PostBluesky