R. Skyner

The paper identifies covalent molecular glue inhibitors that stabilize a non-productive Kalirin-Rac1 complex, inhibiting nucleotide exchange and reducing GEF turnover.

The paper introduces ValDX, a framework to validate and quantify uncertainty in HDX-MS data integration with protein structural ensembles, showing it outperforms conventional metrics in distinguishing correct from incorrect models.

The paper introduces IF-SitePred, a method for predicting protein-ligand binding sites using learned protein representations, showing improved performance on predicted structures and simulated novel proteins.

This study characterizes SARS-CoV-2 NSP15 endoribonuclease, identifies its allosteric properties, and discovers new allosteric sites for inhibitor development.

This study presents crystal structures of SARS-CoV-2 NSP13 and identifies druggable pockets, revealing potential targets for antiviral drug development through fragment screening.

The paper identifies fragment hits against SARS-CoV-2 main protease using crystallography and mass spectrometry, revealing structural insights for drug design.