Muh‐Ching Yee

HLA-Resolve: Four-field HLA typing and MHC variant detection from long-read hybrid capture

HLA-Resolve improves HLA typing and MHC variant detection using long-read sequencing and hybrid capture, achieving high accuracy across diverse samples.

Leveraging Health Systems Data to Characterize a Large Effect Variant Conferring Risk for Liver Disease in Puerto Ricans

The paper identifies a risk variant for liver disease in Puerto Ricans by integrating EHR and genomic data, showing a dose-dependent association with disease severity.

Rapid response to the Alpha-1 Adrenergic Agent Phenylephrine in the Perioperative Period is Impacted by Genomics and Ancestry

This study identifies genetic factors influencing blood pressure response to phenylephrine in perioperative settings, revealing population-specific differences and rare variants associated with non-response.

Genomic insights into the domestication of the chocolate tree, Theobroma cacao L.

The paper sequenced 200 genomes of Theobroma cacao to show that domestication of the Criollo population occurred around 3,600 years ago, with strong selection on genes related to anthocyanin, theobromine metabolism, and disease resistance, and found a negative correlation between Criollo ancestry and bean yield.