Author

Thomas T. Joseph

University of PennsylvaniaORCID 0000-0003-1323-3244Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genomics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Grace H. BranniganiD· 2 shared Aniwaa Owusu ObengiD· 1 shared CBIPM Genomics Team· 1 shared Connor PitmaniD· 1 shared Eimear E. KennyiD· 1 shared Erwin P. Bottinger· 1 shared Ezry Santiago-McRaeiD· 1 shared Filip Van PetegemiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBioinformatics

Grace H. BranniganORCID

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3 papers

Recent·Most cited

BioinformaticsJournal of Chemical Information and ModelingPeer-reviewedJan 13, 2026

The blobulator: a toolkit for identification and visual exploration of hydrophobic modularity in protein sequences

Connor Pitman, Ezry Santiago-McRae, Ruchi Lohia…·Grace H. Brannigan

The blobulator toolkit identifies and visualizes hydrophobic modules in protein sequences using the blobulation algorithm, with applications across different protein types.

DOI 10.1021/acs.jcim.5c01585

protein sequencestatistical model

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Pharmacology & ToxicologyBritish Journal of AnaesthesiaPeer-reviewedSep 19, 2024

Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1)

Thomas T. Joseph, Weiming Bu, Omid Haji‐Ghassemi…·Roderic G. Eckenhoff

This study shows propofol directly binds and inhibits RyR1, reducing Ca2+ release and potentially protecting against malignant hyperthermia.

7 citations

humanexperimental assay

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GenomicsThe Pharmacogenomics JournalPeer-reviewedNov 9, 2020

Rapid response to the Alpha-1 Adrenergic Agent Phenylephrine in the Perioperative Period is Impacted by Genomics and Ancestry

Stéphane Wenric, Janina M. Jeff, Thomas T. Joseph…·Eimear E. Kenny

This study identifies genetic factors influencing blood pressure response to phenylephrine in perioperative settings, revealing population-specific differences and rare variants associated with non-response.

2 citations

humanbulk RNA-seq

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