Pauline C. Ng

Early identification of rare disease using deep phenotyping of electronic health records

This study uses machine learning on electronic health records to identify rare genetic disorders early, achieving up to 89% early detection with over a year lead time for some conditions.

Large-scale whole-genome sequencing of three diverse Asian populations in Singapore

This study presents whole-genome sequencing data from 4,810 Singaporeans across three ethnic groups, revealing genetic structure, admixture, and improved imputation for Asian and Oceanian populations.

Genomic insights into the domestication of the chocolate tree, Theobroma cacao L.

The paper sequenced 200 genomes of Theobroma cacao to show that domestication of the Criollo population occurred around 3,600 years ago, with strong selection on genes related to anthocyanin, theobromine metabolism, and disease resistance, and found a negative correlation between Criollo ancestry and bean yield.