Sander M. Houten

Odd-chain dicarboxylic acid feeding recapitulates the biochemical phenotype of glutaric aciduria type-1 in mice

This study shows that feeding mice odd-chain dicarboxylic acids reproduces the biochemical features of glutaric aciduria type-1.

A multiomic network approach uncovers disease modifying mechanisms of inborn errors of metabolism

The paper identifies modifier pathways for inborn errors of metabolism using multiomic data and gene regulatory networks from healthy populations.

A cold-inducible phospholipid--protein interaction in brown fat mitochondria optimizes thermogenic capacity

The paper identifies LPCAT3 as a cold-regulated enzyme that generates AA-PE in BAT mitochondria, enhancing ETC efficiency and thermogenesis.

Recessive pathogenic variants in MCAT cause combined oxidative phosphorylation deficiency

The paper identifies biallelic MCAT variants in a patient with combined oxidative phosphorylation deficiency and shows reduced ETC complex subunits and enzyme activities.

Leveraging Health Systems Data to Characterize a Large Effect Variant Conferring Risk for Liver Disease in Puerto Ricans

The paper identifies a risk variant for liver disease in Puerto Ricans by integrating EHR and genomic data, showing a dose-dependent association with disease severity.

A novel approach of human geroprotector discovery by targeting the converging subnetworks of aging and age-related diseases

This paper introduces ANDRU, a human data-driven approach to discover geroprotectors by targeting aging and age-related disease subnetworks, identifying potential targets and compounds in adipose and artery tissues.