Metabolic Perturbation Exacerbates Sinoatrial Node Dysfunction in Heart Failure
Lu Ren, Yu Liu, Daphne Agostina Diloretto, Mengjie Xie, Yuting Pan, Yang Zheng, Arianne Caudal, Wenshu Zeng, Ryan L. Woltz, Danielle H Shin, Ye Dai, Rosmery Rodriguez, Richard Q. Ngo, Guy A Perkins, Gabriela Grigorean, , Phung N. Thai
This study identifies ceramides as mediators of mitochondrial dysfunction in sinoatrial node cells during heart failure, suggesting they as potential therapeutic targets.
bioRxiv · Oct 2, 2026 · PreprintPhysiology