Guy A Perkins

This study identifies ceramides as mediators of mitochondrial dysfunction in sinoatrial node cells during heart failure, suggesting they as potential therapeutic targets.

This study investigates how calorie restriction modulates beta cell Ca2+ homeostasis and network connectivity, finding that CR beta cells exhibit faster, shorter Ca2+ oscillations and reduced network connectivity.

The paper identifies AKAP1 as a critical regulator of mitochondrial and synaptic homeostasis in glaucoma, showing its role in neuroprotection and axon regeneration through gene therapy in mouse models.

This study shows that restoring AIBP expression in glaucomatous retinas protects retinal ganglion cells and reduces neuroinflammation in mouse models.

This study shows that AIBP regulates TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer's disease, reducing neuroinflammation and neurodegeneration.

This study shows that activating soluble adenylyl cyclase (sAC) protects retinal ganglion cells from oxidative stress by preserving mitochondrial function and structure.

The paper analyzes mitochondrial morphology in mouse cerebellum neurons using 3D TEM data to quantify structural features that influence metabolic output.

This study shows that loss of AKAP1 leads to Drp1 dephosphorylation, mitochondrial fragmentation, and RGC dysfunction in glaucoma, suggesting AKAP1 as a therapeutic target.