The paper analyzes G6PD variant distribution in sub-Saharan Africa and highlights potential risks of using chloroquine/hydroxychloroquine for COVID-19 due to G6PD deficiency.

26 citations

humanwhole-genome sequencing

𝕏 PostBluesky

GeneticsbioRxivPreprintJun 14, 2020

The extent and impact of variation in ADME genes in sub-Saharan African populations

Jorge da Rocha, Houcemeddine Othman, Gerrit Botha…·Scott Hazelhurst

This study characterizes ADME gene variation in sub-Saharan African populations, identifying novel variants and highlighting the need for tailored pharmacogenomic approaches.

7 citations

humanwhole-genome sequencing

𝕏 PostBluesky

GeneticsPLoS neglected tropical diseasesPeer-reviewedOct 23, 2017

Candidate genes-based investigation of susceptibility to Human African Trypanosomiasis in Côte d’Ivoire

Bernardin Ahouty, Mathurin Koffi, Hamidou Ilboudo…·Assanvo Simon-Pierre N’Guetta

This paper investigates genetic associations with susceptibility to Human African Trypanosomiasis in Côte d’Ivoire using a candidate gene approach and finds suggestive but non-significant associations in several immune-related genes.

18 citations

humanGWAS summary statistics

𝕏 PostBluesky

GenomicsbioRxivPreprintOct 12, 2017

Evidence of population specific selection inferred from 289 genome sequences of Nilo-Saharan and Niger-Congo linguistic groups in Africa

Julius Mulindwa, Harry A. Noyes, Hamidou Ilboudo…·Enock Matovu

The paper analyzes 289 genome sequences from Nilo-Saharan and Niger-Congo populations to identify population-specific selection signatures linked to disease resistance.

2 citations

humanwhole-genome sequencing

𝕏 PostBluesky