This study uses long-read sequencing to analyze VSG diversity in T. brucei infections, revealing higher expressed diversity and early mosaic gene formation than previously observed.

PLoS neglected tropical diseases · Apr 3, 2019Peer-reviewedGenomics

No evidence for association with APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations

Magambo Phillip Kimuda, Harry A. Noyes, Julius Mulindwa, John Enyaru, Vincent Pius Alibu, Issa Sidibé, Dieuodonne Mumba, Christiane Hertz‐Fowler, Annette MacLeod, Özlem Taştan Bishop, Enock Matovu

The paper investigates associations between APOL1 variants and HAT risk in Ugandan populations, finding no significant associations after correction for multiple testing.

PLoS neglected tropical diseases · Feb 22, 2018Peer-reviewedGenetics

Candidate genes-based investigation of susceptibility to Human African Trypanosomiasis in Côte d’Ivoire

Bernardin Ahouty, Mathurin Koffi, Hamidou Ilboudo, Gustave Simo, Enock Matovu, Julius Mulindwa, Christiane Hertz‐Fowler, Bruno Bucheton, Issa Sidibé, Vincent Jamonneau, Annette MacLeod, Harry A. Noyes, Assanvo Simon-Pierre N’Guetta

This paper investigates genetic associations with susceptibility to Human African Trypanosomiasis in Côte d’Ivoire using a candidate gene approach and finds suggestive but non-significant associations in several immune-related genes.

PLoS neglected tropical diseases · Oct 23, 2017Peer-reviewedGenetics

Evidence of population specific selection inferred from 289 genome sequences of Nilo-Saharan and Niger-Congo linguistic groups in Africa

Julius Mulindwa, Harry A. Noyes, Hamidou Ilboudo, Oscar A. Nyangiri, Mathurin Koffi, Dieudonné Mumba Ngoyi, Gustave Simo, John Enyaru, John Chisi, Martin Chitolongo Simuunza, Pius Alibu, Vincent Jamonneau, Annette MacLeod, Bruno Bucheton, Christiane Hertz‐Fowler, , Enock Matovu

The paper analyzes 289 genome sequences from Nilo-Saharan and Niger-Congo populations to identify population-specific selection signatures linked to disease resistance.

bioRxiv · Oct 12, 2017 · PreprintGenomics