Author

Caroline A. Langley

University of WashingtonORCID 0000-0002-0459-0568Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:comparative / phylogenetic analysis· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:multiple species· 1 Research Focus:phylogenetics / evolution· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Harmit Singh MalikiD· 2 shared Michael EmermaniD· 2 shared Jeannette L. TenthoreyiD· 1 shared Michelle LillyiD· 1 shared Peter A. DietzeniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 8 mutual co-author links

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2 shared papersMicrobiology

Harmit Singh MalikORCID

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2 papers

Recent·Most cited

Strain-Specific Epistasis Shapes Fitness Landscapes of APOBEC3G Antagonism By HIV-1 Vif Proteins

Caroline A. Langley, Michelle Lilly, Harmit Singh Malik, Michael Emerman

The paper maps mutational landscapes of HIV-1 Vif proteins to understand how they antagonize APOBEC3G, revealing strain-specific epistasis and structural flexibility.

Science Advances · Jul 23, 2026Peer-reviewedMicrobiology

Antiviral Mx proteins have an ancient origin and widespread distribution among eukaryotes

Caroline A. Langley, Peter A. Dietzen, Michael Emerman, Jeannette L. Tenthorey, Harmit Singh Malik

The paper traces the evolutionary origins of Mx proteins, showing they predate the interferon system and are widespread across eukaryotes, including fungi, plants, and early-branching lineages.

Proceedings of the National Academy of Sciences · Jan 24, 2025Peer-reviewedEvolutionary Biology