Michelle Lilly

This study identifies structural adaptability in HIV-2 Vif that enables broad antagonism of APOBEC3G through conformational selection.

The paper maps mutational landscapes of HIV-1 Vif proteins to understand how they antagonize APOBEC3G, revealing strain-specific epistasis and structural flexibility.

This study identifies epitope targeting as the main determinant of ADCC activity in SARS-CoV-2 antibodies, showing that moderate binding and not SHM or neutralization potency drives immune cell activation.

This study shows that re-infection with SARS-CoV-2 leads to broader and more potent antibodies against diverse sarbecovirus strains compared to antibodies from a prior infection.

This study identifies cross-reactive antibodies against SARS-CoV-2 and related sarbecoviruses that target conserved epitopes and show broad neutralization potential.

This paper identifies diverse functional antibodies targeting the S2 subunit of SARS-CoV-2 spike, including one with broad neutralization activity across multiple coronaviruses.