Ryan M. Mulhern

This paper shows that 2-hydroxyglutarate (2HG) alters fatty acid partitioning, reducing lipotoxic stress by shifting fatty acids toward storage and away from oxidation and membrane synthesis.

This paper discovers and optimizes a CNS-penetrant covalent inhibitor of PIKfyve, DUN058, showing sustained target occupancy and modulation of protein clearance pathways in vivo.