Niv Vigder

This paper shows that 2-hydroxyglutarate (2HG) alters fatty acid partitioning, reducing lipotoxic stress by shifting fatty acids toward storage and away from oxidation and membrane synthesis.

This study identifies alanine as a critical metabolite regulated by TGF-β that supports myofibroblast differentiation in pulmonary fibrosis through GPT2 and SLC38A2.

This study identifies branched chain α-ketoacids (BCKAs) as novel signaling metabolites that activate HIF1α signaling in normoxia and modulate vascular smooth muscle cell function in pulmonary vascular disease.

This study shows that myeloperoxidase (MPO) activity in atherosclerotic plaques predicts atherothrombosis in rabbits and correlates with ruptured human atheroma.

The paper shows that inhibiting lactate transporters MCT1 and MCT4 reduces myofibroblast differentiation and pulmonary fibrosis in vitro and in vivo.