Dynamic chromatin regulatory landscape of human CAR T cell exhaustion
David G. Gennert, Rachel C. Lynn, Jeffrey M. Granja, Evan W. Weber, Maxwell R. Mumbach, Yang Zhao, Zhana Duren, Elena Sotillo, William James Greenleaf, Wing Hung Wong, Ansuman T. Satpathy, Crystal Lee Mackall, Howard Y. Chang
The paper examines dynamic chromatin changes in human CAR T cells during exhaustion, identifying regulatory networks and enhancer roles in exhaustion-associated genes.
Proceedings of the National Academy of Sciences · Jul 20, 2021Peer-reviewedGenomics