Maxwell R. Mumbach

Chromatin activity identifies differential gene regulation across human ancestries

The paper identifies differential gene regulation across human ancestries by analyzing chromatin activity and finds enhancers show stronger selection signals than promoters.

KLF4 Recruits SWI/SNF to Increase Chromatin Accessibility and Reprogram the Endothelial Enhancer Landscape under Laminar Shear Stress

The paper shows how KLF4 interacts with SWI/SNF to increase chromatin accessibility at enhancers under laminar shear stress, promoting endothelial homeostasis and suppressing inflammation.

Dynamic chromatin regulatory landscape of human CAR T cell exhaustion

The paper examines dynamic chromatin changes in human CAR T cells during exhaustion, identifying regulatory networks and enhancer roles in exhaustion-associated genes.

Single-cell epigenomic identification of inherited risk loci in Alzheimer's and Parkinson's disease

The paper uses single-cell epigenomic data to identify functional SNPs associated with Alzheimer's and Parkinson's disease, revealing novel gene-disease associations and regulatory mechanisms.

Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion

The paper uses scATAC-seq to analyze chromatin accessibility in immune cell development and tumor microenvironments, identifying regulatory elements and trajectories associated with cell differentiation and therapy response.

Coupled single-cell CRISPR screening and epigenomic profiling reveals causal gene regulatory networks

Perturb-ATAC combines CRISPR perturbations with single-cell ATAC-seq to identify gene regulatory networks in human cells.

Morphogen-Lineage Selector Interactions During Surface Epithelial Commitment

The paper investigates how morphogens and p63 interact to regulate chromatin dynamics during keratinocyte differentiation from hESCs, revealing p63's dependence on morphogenetic signaling for long-range chromatin interactions.

Enhancer connectome in primary human cells reveals target genes of disease-associated DNA elements

This paper uses HiChIP to map enhancer-promoter interactions in primary human cells, linking disease-associated DNA variants to their target genes.

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

Omni-ATAC improves ATAC-seq by reducing background noise and enabling analysis of frozen tissues, revealing disease-associated DNA element activities in human brain structures.