This study maps dicentric chromosome breakage hotspots in Drosophila and identifies structural complexity, replication-transcription conflict, and transposon involvement as key factors.

bioRxiv · Jul 13, 2026 · PreprintGenetics

Drosophila ring chromosomes interact with sisters and homologs to produceanaphase bridges in mitosis.

Ho-Chen Lin, Mary M Golic, Hunter J. Hill, Katherine F. Lemons, Truc T. Vuong, Madison Smith, Forrest Golic, Kent G. Golic

The paper identifies five causes of anaphase bridges formed by ring chromosomes in Drosophila melanogaster, including sister chromatid catenation and homolog capture.

Genetics · Oct 25, 2024Peer-reviewedGenetics

Dicentric chromosome breakage in Drosophila melanogaster is influenced by pericentric heterochromatin and reveals a novel class of fragile site.

Hunter J. Hill, Danielle Bonser, Kent G. Golic

The paper studies dicentric chromosome breakage in Drosophila melanogaster and finds that breakage hotspots are not conserved and are influenced by pericentric heterochromatin and centromere origin.

bioRxiv · Oct 13, 2022 · PreprintGenetics

Site-specific recombination between inverted target sites generates dicentric/acentric chromosomes.

Simon William Abraham Titen, Makenna T. B. Johnson, Mario R. Capecchi, Kent G. Golic

The paper shows that recombination between inverted target sites on sister chromatids produces dicentric and acentric chromosomes, which can negatively affect cell viability and behavior.

Genetics · Jun 25, 2020Peer-reviewedGenetics