Cancer BiologybioRxivPreprint
✦ In-depth digest
Targeting MAT2A-S-adenosylmethionine (SAM) Axis Attenuates DNA Damage Response and Cancer Stemness to Increase Platinum Sensitivity in Ovarian Cancer
Shu Zhang, Zhen Fu, Yanchi Zhou…·Kenneth P. Nephew
Blocking MAT2A-driven SAM synthesis in ovarian cancer cells prevents cisplatin-induced DNA hypermethylation, impairs DNA repair signaling, and blocks stem cell enrichment, sensitizing MTAP-proficient and MTAP-deficient lines.