The paper introduces GPD, a framework using gene co-expression programs to create an organism-wide cell atlas, revealing disease-related gene programs across tissues.

DOI 10.1101/2025.10.29.685322

humanscRNA-seq

𝕏 PostBluesky

Systems BiologyCell SystemsPeer-reviewedDec 1, 2024

Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening

Matteo Gentili, Rebecca J. Carlson, Bingxu Liu…·Nir Hacohen

The paper identifies regulators of STING trafficking through genome-wide screening and characterizes their functional impact on STING signaling.

13 citations

humanCRISPR screen

𝕏 PostBluesky

GenomicsbioRxivPreprintMar 17, 2024

CROPseq-multi: a universal solution for multiplexed perturbation in high-content pooled CRISPR screens

Russell T. Walton, Yue Qin, Bryce Kirby…·Paul C. Blainey

CROPseq-multi enables multiplexed CRISPR perturbations across various screening methods with improved barcode detection and compatibility.

24 citations

CRISPR screenexperimental assay

𝕏 PostBluesky

Systems BiologyNaturePeer-reviewedNov 24, 2021

Mapping cell structure across scales by fusing protein images and interactions

Yue Qin, Edward L. Huttlin, Casper F. Winsnes…·Trey E. Ideker

The paper integrates protein imaging and interaction data to create a unified map of eukaryotic cell structure, revealing new subcellular systems and protein associations.

82 citationstop 3%

humanimaging

𝕏 PostBluesky