Author

Byunguk Kang

Broad InstituteORCID 0009-0004-5540-7745Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Neuroscience· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:CRISPR screen· 2 Organism:human· 2 Research Focus:perturbation response prediction· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Organism:Drosophila· 1

Frequent Co-Authors

Ernest FraenkeliD· 2 shared Matthew Joseph LeventhaliD· 2 shared Ralda NehmeiD· 2 shared Samouil L. FarhiiD· 2 shared Serwah A. DanquahiD· 2 shared Bryce Kirby· 1 shared Camila A. ZanellaiD· 1 shared Christopher NgiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersSystems Biology

Ernest FraenkelORCID

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3 papers

Recent·Most cited

An integrative systems-biology approach defines mechanisms of Alzheimer's disease neurodegeneration

Matthew Joseph Leventhal, Camila A. Zanella, Byunguk Kang, Jiajie Peng, David Gritsch, Zhixiang Liao, Hassan Bukhari, Tao Wang, Ping‐Chieh Pao, Serwah A. Danquah, Joseph Benetatos, Ralda Nehme, Samouil L. Farhi, Li‐Huei Tsai, Xianjun Dong, , Ernest Fraenkel

This study integrates multi-omics data from Drosophila and human Alzheimer's disease models to identify pathways involved in neurodegeneration.

Nature Communications · May 20, 2025Peer-reviewedSystems Biology

CellPHIE: Integrating Pathway Discovery With Pooled Profiling of Perturbations Uncovers Pathways of Huntington's Disease, Including Genetic Modifiers of Neuronal Development and Morphology

Byunguk Kang, Michael A. Murphy, Christopher Ng, Matthew Joseph Leventhal, Nhan C. Huynh, Egun Im, Serwah A. Danquah, David E. Housman, Ralda Nehme, Samouil L. Farhi, Ernest Fraenkel

The paper integrates pathway discovery with pooled genetic perturbation to identify modifiers of Huntington's disease, revealing genes involved in neuronal development and morphology.

bioRxiv · Feb 19, 2025 · PreprintNeuroscience

CROPseq-multi: a universal solution for multiplexed perturbation in high-content pooled CRISPR screens

Russell T. Walton, Yue Qin, Bryce Kirby, J Owen Andrews, Mikko Taipale, Byunguk Kang, Paul C. Blainey

CROPseq-multi enables multiplexed CRISPR perturbations across various screening methods with improved barcode detection and compatibility.

bioRxiv · Mar 17, 2024 · PreprintGenomics