Edward L. Huttlin

Survey of the human proteostasis network: the ubiquitin-proteasome system

The paper provides a comprehensive survey of the ubiquitin-proteasome system (UPS) and estimates its size and scope within the human proteostasis network.

LAMPrEY: a Python-based automated quality control tool for large-scale proteomics datasets

LAMPrEY is a Python-based quality control tool for large-scale proteomics datasets that automates processing and analysis with MaxQuant and RawTools, enabling reproducible and rapid data interpretation.

A unified photosensitizer platform for in situ DNA, RNA, and protein directed proximity labeling

The paper introduces POCA, a photosensitizer platform for proximity labeling of proteins, RNA, and DNA in fixed cells without genetic engineering, demonstrating its utility across multiple molecular targets.

Mapping cell structure across scales by fusing protein images and interactions

The paper integrates protein imaging and interaction data to create a unified map of eukaryotic cell structure, revealing new subcellular systems and protein associations.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

The paper creates two large-scale cell-line-specific human interactomes using affinity-purification mass spectrometry and identifies shared and cell-specific protein interactions.