David P. Giedroc

This paper identifies a self-S-sulfonation mechanism in bacterial persulfide dioxygenase CstB that converts thiol persulfides to thiosulfate without sulfite release.

The paper investigates how allostery evolves in the ArsR superfamily by showing that functional diversification arises from internal dynamics rather than large conformational changes.

This paper evolves DNA operators to enhance protein-DNA interactions for better transcriptional control in cell-free systems.

This paper identifies a 'self-gapping' mechanism in bacterial COG0523 metallochaperones where the C-terminal domain activates GTP hydrolysis via an arginine finger and lysine residue, revealing a novel regulatory mechanism.

The paper identifies alkyl CH···S hydrogen bonds as critical for molecular recognition of ergothioneine by the microbial transporter EgtUC.

This study uses chemoproteomics to show that calprotectin stress in Acinetobacter baumannii leads to undermetalation of metalloproteomes, impairing key metabolic and cellular processes.

This paper identifies genes essential for Staphylococcus aureus growth in CF sputum and shows that calprotectin and cysteine limit its growth.

A cell-free platform pairing T7 RNA polymerase, allosteric transcription factors and DNA templates yields fluorescent RNA output to detect antibiotics, small molecules and metals in water.