Ann Carolyn McKee

This study identifies proteomic changes in CTE brains, linking proteasome and ribosome dysfunction to disease progression and clinical features.

The paper identifies somatic genomic alterations in neurons from CTE patients, finding patterns similar to Alzheimer's disease and suggesting mechanisms beyond repetitive head impacts.

This paper introduces an age-informed attention-based MIL model to predict AT8 density in neuropathological images, improving diagnostic accuracy and interpretability.

The paper shows that cortical circuit principles predict the progression of tauopathy in CTE by aligning p-tau pathology with laminar connection patterns in human brains.

This study identifies differentially expressed genes and pathways in Alzheimer's disease brain tissue from African American donors, highlighting potential targets for treatment.

This study shows that repetitive head impacts in young athletes cause neuronal loss and neuroinflammation before CTE pathology, with specific cellular changes linked to disease progression.

This paper introduces a multi-scale imaging technique combining PSOCT and 2PM to enable label-free, high-resolution analysis of human brain structure and pathology.

The paper compares gene expression changes in early and late stages of chronic traumatic encephalopathy (CTE) and identifies factors influencing disease expression.

The paper identifies differentially expressed mRNAs and microRNAs in human brain tissues associated with obesity and BMI using RNA sequencing from multiple cohorts.

This study identifies JADE1 as a novel genetic factor in tauopathy through genome-wide association and functional validation in human and Drosophila models.

This study identifies molecular and cellular changes in oligodendrocytes and astrocytes in CTE using single-nucleus RNA sequencing and histological analysis.