Sequentially Self-Assembled Supramolecular Nanocomplexes Enable Systemic Cas9 RNP Delivery and In Vivo Tumor Genome Editing
Takumi Matsuo, Yuto Honda, Toshizumi Chino, Takahiro Nomoto, Yuriko Osakabe, Yutaka Miura, Nobuhiro Nishiyama
This paper develops a supramolecular nanocomplex for systemic CRISPR-Cas9 delivery, achieving higher gene editing efficiency in tumors compared to free RNPs.
ACS Applied Materials & Interfaces · Oct 1, 2026Peer-reviewedBioengineering