Yuriko Osakabe

This paper develops a supramolecular nanocomplex for systemic CRISPR-Cas9 delivery, achieving higher gene editing efficiency in tumors compared to free RNPs.

This study investigates the role of C4H in rice lignin biosynthesis, showing it is essential but dispensable due to the compensatory PTAL pathway.

The paper shows that disrupting CAld5H and PMT genes in rice eliminates syringyl lignin, revealing a grass-specific pathway for p-coumarate conjugates and lineage-dependent lignin polymerization.

This study identifies Cas10d as a multi-functional nuclease in CRISPR type I-D system, enabling targeted mutagenesis in human cells with specific deletion and insertion capabilities.