(R,S)-ketamine's rapid-acting antidepressant effects are modulated by NR2B- containing NMDA receptors on adult-born hippocampal neurons
Nicholas E. Bulthuis, Josephine Cecelia McGowan, Liliana R. Ladner, Christina T. LaGamma, Sean C. Lim, Claire X. Shubeck, Rebecca A. Brachman, Ezra Sydnor, Ina P. Pavlova, Dong-oh Seo, Michael R. Drew, Christine Ann Denny
This study shows that NR2B-containing NMDA receptors on adult-born hippocampal neurons are necessary for (R,S)-ketamine's rapid-acting antidepressant effects in male and female mice.
bioRxiv · Nov 28, 2023 · PreprintNeuroscience