Christine Ann Denny

Altered striatal dopamine regulation in ADGRL3 knockout mice

This study examines how ADGRL3 knockout affects dopamine release in mice, finding increased ex vivo release and reduced in vivo task-induced signals in the nucleus accumbens.

Novel, small molecules targeting the 5-HT4R receptor protect against stress-induced maladapative behavior with efficacy across age

The paper develops and tests novel 5-HT4R-targeting compounds that reduce stress-induced maladaptive behaviors in mice, showing efficacy across age groups.

A tale of two receptors: simultaneous targeting of NMDARs and 5-HT4Rs exerts additive effects against stress

This study investigates the combined effects of (R,S)-ketamine and prucalopride on stress-induced behaviors and neural activity, finding additive benefits in reducing fear, despair, and hyponeophagia.

Sex-Specific Effects of Anxiety on Cognition and Activity-Dependent Neural Networks: Insights from (Female) Mice and (Wo)Men

The paper examines sex-specific effects of anxiety on cognition and neural networks in mice and humans, finding earlier cognitive decline in female AD mice and faster dementia progression in anxious female humans.

Anesthesia unconsciousness recruits dynamic parabrachial activity within a distributed brain-wide ensemble

This study identifies a brain-wide neural ensemble involved in anesthesia-induced unconsciousness, with the lateral parabrachial nucleus as a central hub.

Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions.

The paper investigates how ketamine's metabolism via hepatic CYP450 enzymes affects its antidepressant effects, finding that (6)-HNKs mediate sustained antidepressant actions.

A SMARTTR workflow for multi-ensemble atlas mapping and brain-wide network analysis

The paper introduces SMARTTR, an R package for brain-wide mapping and network analysis of multiple ensembles, and demonstrates its application to learned helplessness studies.

A multiple Arc (mArc) tagging system to uncover the organizational principles of multiple memories

The paper introduces a multiple Arc (mArc) system to tag two Arc+ ensembles and investigates how context, time, and valence influence DG ensemble reactivation.

(R,S)-ketamine's rapid-acting antidepressant effects are modulated by NR2B- containing NMDA receptors on adult-born hippocampal neurons

This study shows that NR2B-containing NMDA receptors on adult-born hippocampal neurons are necessary for (R,S)-ketamine's rapid-acting antidepressant effects in male and female mice.

Persistent increases of PKMζ in memory-activated neurons trace LTP maintenance during spatial long-term memory storage

The paper shows that persistent PKMζ increases in specific hippocampal neurons during LTP maintenance and spatial memory storage, indicating its role in long-term memory.

Optogenetic reactivation of prefrontal social memory trace mimics social buffering of fear

The paper shows that optogenetic reactivation of socially-active neurons in the infralimbic prefrontal cortex mimics social buffering of fear in mice.

Prophylactic efficacy of 5-HT4R agonists against stress

This study tests if 5-HT4R agonists can prevent stress-induced behaviors in mice, finding that some are effective as prophylactics.

Ovarian hormones mediate the prophylactic efficacy of (R,S)-ketamine and (2R,6R)-hydroxynorketamine in female mice

This study shows that (R,S)-ketamine and (2R,6R)-hydroxynorketamine prevent stress-induced depressive-like behavior in female mice, with ovarian hormones mediating their efficacy.