Josephine Cecelia McGowan

This study shows that early life stress in mice leads to social behavior deficits and altered stress biomarkers in adolescence, with effects persisting across generations.

The paper investigates prefrontal cortex (PFC) neuronal activity during a complex spatial working memory task in rodents and finds retrospective mnemonic representations of spatial information during the delay phase, particularly on error trials.

The paper investigates how ketamine's metabolism via hepatic CYP450 enzymes affects its antidepressant effects, finding that (6)-HNKs mediate sustained antidepressant actions.

This study shows that NR2B-containing NMDA receptors on adult-born hippocampal neurons are necessary for (R,S)-ketamine's rapid-acting antidepressant effects in male and female mice.