Author

Kenta Horie

Chiba UniversityORCID 0000-0003-4175-1014Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Georg A. HolländeriD· 2 shared Hiroto Ishii· 2 shared Jun‐ichiro InoueiD· 2 shared Maki Miyauchi· 2 shared Naho Hagiwara· 2 shared Nobuaki YoshidaiD· 2 shared Nobuko AkiyamaiD· 2 shared Rin Endo· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Georg A. HolländerORCID

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2 papers

Recent·Most cited

A chromatin relay from AIRE to ETS transcription factors sustains peripheral antigen expression in the thymic mimetic cells to ensure central tolerance.

Kenta Horie, Takahisa Miyao, Yuko Yamagata, Yuki Takakura, Fuyoko Suzuki, Naho Hagiwara, Rin Endo, Maki Miyauchi, Hiroto Ishii, Wataru Muramatsu, Yuki Goda, Tatsuya Ishikawa, Jun‐ichiro Inoue, Nobuaki Yoshida, N Yamaguchi, , Taishin Akiyama

The paper identifies EHF and ELF3 as key ETS transcription factors that sustain AIRE-primed gene expression in post-AIRE mimetic thymic epithelial cells, ensuring central tolerance.

bioRxiv · Feb 5, 2026 · PreprintImmunology

ASCL1 primes medullary thymic epithelial cell programs required for central tolerance

Nobuko Akiyama, Kenta Horie, Kano Namiki, Jen-Chien Chang, Maki Miyauchi, Takahisa Miyao, Nanako Uchida, Naho Hagiwara, Masaki Yoshida, Mizuki Morota, Tsukasa Kouno, Miki Kojima, Jonathan Moody, Yoshinari Ando, Hirotake Ichise, , Taishin Akiyama

The paper identifies ASCL1 as a key regulator of mTEC function and central tolerance by analyzing single-cell RNA sequencing data from thymoma patients and mouse models.

bioRxiv · Aug 6, 2025 · PreprintImmunology