Spatial organisation and homeostasis of epithelial lineages at the gastroesophageal junction is regulated by the divergent Wnt mucosal microenvironment
Naveen Kumar, Rajendra Kumar Gurumurthy, Pon Ganish Prakash, Shilpa Mary Kurian, Christian Wentland, Volker Brinkmann, Hans‐Joachim Mollenkopf, Tobias Krammer, Christophe Toussaint, Antoine‐Emmanuel Saliba, Matthias Biebl, Christian Juergensen, Bertram J. Wiedenmann, Thomas F. Meyer, Cindrilla Chumduri
The paper identifies the spatial organisation and regulatory mechanisms of epithelial lineages at the gastroesophageal junction using multi-omics approaches and shows that Wnt microenvironments maintain homeostasis without lineage plasticity.
bioRxiv · Aug 5, 2021 · PreprintDevelopmental Biology